Jimi Hendrix: Arguably the finest guitarist of all time, Jimi Hendrix dazzled on a number of levels – as a performer, a musician and an innovator. Engel explains that Hendrix had a unique approach even to working around his left-handedness: "Jimi Hendrix strung his guitars left-handed; however most people who aren't really closely familiar with his work think that he plays upside down because he uses right-handed guitars for the most part. But he took a right-handed instrument and had them restrung left-handed."

Tony Iommi: Judas Priest's Rob Halford once introduced Black Sabbath's Tony Iommi as "the man who invented the heavy metal riff." With an SG perennially in hand, the English-born guitarist, now 63, overcame not only the hardship of being a left-handed guitarist in a right-handed world, but he also learned to operate a guitar having had the tips of two of his fingers sliced off in an factory accident.